Africa faces many challenges, such as COVID-19, lack of vaccines, and the rise of China and its influences. However, one of the biggest opportunities in Africa is the chance to craft solutions locally. There are brilliant minds in Africa, and the biggest challenge is engaging them to solve problems in Africa. Similarly, the young population of Africa are in a great position to transform the Africa’s resources into capital. Ladership oof some African countries, however, is inept and corrupt, which inhibits this opportunity. In this panel, which features speakers from Ghana, Nigeria, and Uganda; panelists Fr. George B.N. Adimike, Ph.D.; Michael Matheson Miller; Susan Namulindwa; and Sebastian Spio-Garbrah discuss entrepreneurship in Africa, as well as its economy.